Lateral dissemination and inter-patient transmission ofblaKPC-3: role of a conjugative plasmid in spreading carbapenem resistance

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Sir, Worldwide, most multiply antibiotic-resistant (MAR), and particularly carbapenem-resistant, Acinetobacter baumannii causing infections belong to global clone 1 (GC1) or global clone 2 (GC2). Though there have been incidences where a different clonal group was predominantly responsible for an epidemic outbreak, MAR isolates that are not members of these clones have been observed to cause in...

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Dissemination of an antibiotic resistance plasmid in hospital patient flora.

The 2'' aminoglycoside nucleotidyltransferase, AAD (2''), which adenylates gentamicin, tobramycin, and kanamycin, became prevalent over several months in multiple strains and species of Enterobacteriaceae isolated at one hospital. Eight plasmids with the gene for this enzyme purified from different strains and species isolated at different times had similar EcoRI digestion fragments, indicating...

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A conjugative plasmid, pOLA52, conferring resistance to the antibiotic growth promoter olaquindox has been isolated from Escherichia coli from swine manure. It also confers resistance to ampicillin and chloramphenicol and has a high frequency of transfer between strains of E. coli. Plasmid-borne olaquindox resistance has not been demonstrated before.

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2015

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkv356